【5th.July】Hydrogen-Mediated C-C Bond Formation
日期：2018-07-05
阅读：1054
题目：Hydrogen-Mediated C-C Bond Formation
报告人：Professor Michael J. Krische, The University of Texas at Austin
时间：2018年7月5日下午3点30分
地点：化学楼A楼528
邀请人：涂永强教授，张勇健研究员
“Hydrogen-Mediated C-C Bond Formation”
Professor Michael J. Krische, Ph.D., FRSC, FAAAS
University of Texas at Austin, Department of Chemistry (A5300)
AUSTIN, TX 78712-0165
e-mail: [email protected]
in the advancement of methods for efficient, green chemical synthesis. Progress toward this goal requires a departure from reactants that embody non-native structural elements, including
stoichiometric organometallic reagents, directing/protecting groups and chiral auxiliaries.
Professor Michael J. Krische (B.S. UC Berkeley; PhD Stanford University) has developed a broad,new family of C-C bond formations that merge the characteristics of catalytic hydrogenation
and carbonyl addition. Hydrogenation or transfer hydrogenation of π-unsaturated reactants in the presence of C=X (X = O, NR) bonds delivers products of carbonyl or imine addition.
In related hydrogen auto-transfer reactions, alcohols served dually as reductants and carbonyl proelectrophiles, enabling direct conversion of lower alcohols to higher alcohols. Such
hydrogen-mediated C-C bond formations define a departure from the use of stoichiometric organometallic reagents, and the issues of safety, selectivity, and waste associated with their
use.
Curriculum Vitae:
Michael J. Krische, Professor of Chemistry，University of Texas at Austin，TX,U.S.A.
Email: [email protected] Website: //www.cm.utexas.edu
Professional Positions
Humboldt Senior Research Fellow，Freiburg University (2009-Present)
Robert A. Welch Chair in Science，University of Texas at Austin (9/07-Present),Professor of Chemistry (Direct Promotion from Asst. Prof),University of Texas at Austin (9/04-Present)
Assistant Professor of Chemistry,University of Texas at Austin (9/99-8/03),NIH Post-Doc., Université Louis Pasteur (1/97-8/99),Advisor: Professor Jean-Marie Lehn
Fulbright Fellow, Helsinki University, (9/89-6/90),Advisor: Professor Ari M. P. Koskinen
Selected Honors and Awards
Fellow of the American Association for the Advancement of Science (AAAS) (2017)
Royal Society of Chemistry, Pedler Award (2015)
Eun Lee Lectureship Award, Korea (2015)
Japanese Society for the Promotion of Science (JSPS)
Research Fellowship (2013)
Fellow of the Royal Society of Chemistry (2013)
ACS Cope Scholar Award (2013)
GlaxoSmithKline Scholar Award (2012)
Mukaiyama Award, Society of Synthetic Organic Chemistry, Japan (SSOCJ), 2010
Humboldt Foundation Senior Research Award
(2009-2011)
Freiburg Institute for Advanced Studies (FRIAS)
External Senior Fellow, 1/09- 12/11
Tetrahedron Young Investigator Award (2009)
Novartis Lectureship Award (2008)
Presidential Green Chemistry Challenge Award (2007)
Dowpharma Prize - Creativity in Chiral Chemistry (2007)
ACS Elias J. Corey Award (2007)
Solvias Ligand Prize (2006)
The Society of Synthetic Chemistry, Japan Lectureship on Organic Synthesis (2005)
Johnson & Johnson Focused Giving Award (2005)
Camille Dreyfus Teacher-Scholar Award (2003)
Alfred P. Sloan Research Fellow (2003)
Eli Lilly Granteeship for Untenured Faculty (2002)
Frasch Foundation Award in Chemistry (2002)
Research Corporation, Cottrell Scholar Award (2002)
UT College of Natural Sciences, Teaching Excellence Award (2002)
Thieme Chemistry Journal Award (2001)
National Science Foundation, CAREER Award (2000)
Maître de Conference, Collége de France, 2/99 - 7/99
National Institute of Health, Post-Doctoral Fellow,
Université Louis Pasteur, 1/97-1/99
Veatch Graduate Fellowship, Stanford University,
1/95 - 1/96
Sigma Xi Grantee/Visiting Researcher
Surrey University, UK, 6/90 - 8/90
Fulbright Fellow, Helsinki University, Finland
9/89 - 5/90
Presidents Undergraduate Fellow, UC Berkeley, 9/87 - 6/88
